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The question is not which is "best" in the abstract, but which combinations make the most sense for a given situation

Additionally, there are drug efflux pumps such as p -glycoprotein (P-gp), multidrug resistance associated protein (MRP) and drug metabolic enzymes, at the BBB to remove and/or inactivate small drug molecules from the brain [1]

Wilhelm, K

Model , 2015 , 55 , 12, 2562-2574

GLP-1 Agonists: Treatment Failure Does Not Preclude Prevention The November 2025 announcement from Novo Nordisk that oral semaglutide failed to slow Alzheimers progression in the EVOKE and EVOKE+ trials was widely reported as a setback