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The Science Behind Mounjaro (Tirzepatide) Mounjaro is a dual GIP and GLP-1 receptor agonist, it mimics the action of two key natural gut hormones: GIP = Glucose-Dependent Insulinotropic Polypeptide GLP-1 = Glucagon-Like Peptide-1 These hormones are part of your bodys incretin system , which helps regulate blood sugar and appetite after meals