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Notably, under hypoxic or electron transportlimited conditions, SDH can reverse its activity to reduce fumarate to succinate using electrons from the CoQ 10 pool, a metabolic rerouting, allowing cells to maintain redox balance when oxygen is scarce 77

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The cells were treated with BAs (100 M, 24 h), including CDCA, TMCA, HDCA (T2968, TargetMol) and UDCA (T0700, TargetMol), for GLP-1 measurement and RNA isolation

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To maintain homeostasis, organisms and cells developed a sophisticated enzymatic and non-enzymatic antioxidant defense system including catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) that counteracts excessive ROS levels