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Published rodent and cell-culture work has examined NNMT inhibition in the context of adipocyte metabolism and of methyl-donor and NAD pool dynamics

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Despite being mechanistically different, pyroptosis, ferroptosis, apoptosis, necroptosis act synergistically via shared signaling nodes in DKD, with mitochondrial ROS (mtROS) and serving as a pivotal common mediator (30, 112, 176, 207)

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