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Heart failure therapy by GLP-1RAs Although a meta-analysis of large-scale clinical trials suggested that GLP-1RAs reduce heart failure hospitalizations (HHF) by approximately 10% in patients with diabetes at high cardiovascular risk [22, 23], the treatment effects on the risk of HHF in individual trials other than AMPLITUDE-O were not significant (Tables 1, 2)
A.Hacein-Bey-AbinaS.PayenE.MagnaniA.SemeraroM.MagrinE.et al (2017)
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Orforglipron, a non-peptide GLP-1 receptor agonist, represents another daily oral incretin-based AOM displaying dose-dependent BW and WC reductions at 36 weeks ranging from 9.4 to 14.7% and from 9.6 cm to 13.6 cm with the 12 and 45 mg dose, respectively, in mostly female (59%) patients with a mean age of 54.2 years and BMI 37.9 kg/m 2 44
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