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The resulting Gly-His-Lys-Cu(II) complex shifts the peptide's behavior from a passive ligand to an active modulator of intracellular copper trafficking [2]

At the clinical translational level, novel slow-release HS donors (e.g., GYY4137) have demonstrated dual efficacy in mucosal healing and anti-fibrosis in animal models of IBD (He et al., 2025)

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World Journal of Gastroenterology (PMC) Sikiric P et al

Among those who do start using GLP-1s, over 50% stop due to costs, and as many as 36% stop due to side effects

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