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If patients cannot tolerate a dose increase, the escalation may be delayed
Note, no head-to-head studies of GLP-1RAs and SGLT-2 inhibitors or acarbose are available
Multiple cleavage sites along this chain are vulnerable to pepsin and other proteases
These findings illustrate that optimal intensification strategies are context-dependent and should consider both the magnitude and probability of clinically meaningful benefit
According to the American Diabetes Association (ADA), metformin remains the preferred first-line therapy for T2DM (19)
You can get tirzepatide as an injectable or as oral tablets, and you can get semaglutide as an injectable, liquid oral drops, or fast-dissolving sublingual tablets
