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Therefore, it is possible that the relative activity of tirzepatide at the GLP-1R and GIPR may vary in subjects with and without diabetes as well as with the degree of hyperglycemia

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J Clin Invest 122:30633087 Ajami B, Bennett JL, Krieger C et al (2007) Local self-renewal can sustain CNS microglia maintenance and function throughout adult life

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