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These interactions strengthen the binding and function of GLP-2, consistent with the decreased potencies of R242A (by 5-fold), R242E (by 20-fold), W249A (by 1552-fold) and Y252A (by 5-fold) (Fig

[1] [2] Unlike other GLP-1 agonists that require subcutaneous injection, Rybelsus is formulated as a tablet, offering a more convenient option for patients who prefer oral medication

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