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Valks DM, Cook SA, Pham FH, et al
Once activated, this pathway encourages pulsatile GH release , leading to a downstream increase in Insulin-like Growth Factor 1 (IGF-1) production from the liver a key anabolic hormone responsible for muscle growth, fat metabolism, and cellular repair
S.XiuJ.DuanY.LiC.et al (2012)
These finding is not unexpected since GLP-1 may increase natriuresis through the inhibition of many ion exchangers in the tubules which expression decreases with the progression of CKD and interstitial fibrosis and tubular atrophy 33
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