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Effect of metformin on all-cause mortality and major adverse cardiovascular events: An updated meta-analysis of randomized controlled trials
Therefore, the combined use of GLP-1 RAs with therapies targeting intrahepatic pathways, such as thyroid hormone receptor (THR-) agonists, fibroblast growth factor-21 (FGF21) analogues, and peroxisome proliferator-activated receptor (PPAR) agonists, presents a promising approach for MASH treatment
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Although many research groups have explored ways to enhance absorption, the gastrointestinal tract remains an environment that rapidly disrupts peptide structures through enzymatic cleavage, pH-induced denaturation, and limited permeability across epithelial barriers
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