Resmetirom received FDA approval for the fibrotic stage, but the steatosis stage, where the vast majority of patients sit, has no approved pharmacological intervention
However, it is important to note that neurological symptoms can occur even in the absence of anaemia, particularly in patients taking folic acid supplements, which can mask the blood changes whilst neurological damage progresses
This causes the water in the vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure
When kidney function declines, clearance slows and the level drifts upwards
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In addition to the hydrochloric acid secreted from the stomach, the properly functioning parietal cells also secrete intrinsic factor, however nothing is bound to the intrinsic factor at this point