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Gut health influences inflammation, hormone signaling, microbiome composition, and nutrient metabolism, all of which can impact metabolic function

2018 Jan 9;9(1):113

All experiments were performed in quadruplicate

The primary outcome was a new diagnosis of SIBO following GLP-1 RA exposure

In a 12-month study of 339 Second Nature members published in JMIR Formative Research, members taking tirzepatide (Mounjaro) lost an average of 22.1% of their body weight, and those taking semaglutide (Wegovy) lost 17.1%, in line with the averages seen in the original clinical trials

Additionally, peptide therapy may not be appropriate for individuals taking immunosuppressant medications or those dealing with active systemic infections, autoimmune disorders, or poorly controlled metabolic conditions