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patients typically present a prescription and choose the tier that aligns with their clinical needs

Canto, C

Weight reduction results in cholesterol supersaturation in the bile, thereby increasing the risk of gallstone formation [40]

The Phase 2 trial enrolled participants with obesity and evaluated multiple dose levels over 48 weeks: 1 mg dose: 8.7% average body weight reduction 4 mg dose (escalated from 2 mg): 17.1% average body weight reduction 8 mg dose (escalated from 2 mg): 22.8% average body weight reduction 12 mg dose (escalated from 2 mg): 24.2% average body weight reduction Placebo: 2.1% average body weight reduction Those Phase 2 numbers were striking enough

For ongoing maintenance protocols, though, that advantage matters less

In this primer, Dr