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63 Together, these findings indicate that (i) the sensitivity of tumors to insulin and IGF-1 parallels their response to CR, and (ii) neither the activation status of PI3KAKT per se nor mutation status of individual genes predicts for the sensitivity of tumors to both growth factors and CR

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After injection of anesthetics along the anticipated incisional track (5 mL, 2% lidocaine), an anterolateral thoracotomy was carried out within the left third thoracic interspace