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Sleep and energy improve first, body composition follows at months 2 to 3, and skin and anti-aging effects accumulate through months 4 to 6

Prospective study of changes in the metabolomic profiles of men during their first three months of androgen deprivation therapy for prostate cancer

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Similarly, in mice, gut-derived B cells activated within intestinal lymphoid tissues migrate to the liver during disease progression ( Figure 7F )