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The first six amino acids at the N-terminus of GLP-1 are gone, and the alanine at position 8 is changed to the unnatural dimethyl version (Aib, 2-aminoisobutyric acid) thats to prevent enzymatic breakdown by the DPP-IV enzyme in vivo
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Furthermore, understanding the functionality of the GLP-1R may help in development of more specific GLP-1 analogs (Patterson et al., 2013)
The hexosamine biosynthesis pathway: regulation and function
Why does obesity lower testosterone
M., Chatterjee, R., Marinopoulos, S
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