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Although manifestations of neurological dysfunction often point to TD and may sometimes accompany gastrointestinal beriberi (17, 64), it has been also noted that chronic mild deficiency may present with gastrointestinal symptoms under entirely normal neurological exams in well-nourished, non-alcoholic patients (6568)
Ferreiras research is supported by the Fundao de Amparo Pesquisa do Estado do Rio de Janeiro, Coordination for the Improvement of Higher Education Personnel (CAPES) and National Council for Scientific and Technological Development (CNPq)
The most common adverse effects are gastrointestinal and include nausea, vomiting, diarrhea, constipation, and abdominal pain
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Botulinum toxin is among the most potent toxins known
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Regulatory agencies are moving toward more unified approaches to evaluating nanomedicine and biomaterials, and early engagement with regulators can help teams identify clearer approval pathways (210)
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