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In summary, deficiency of RBX2 results in compromised mitochondrial ubiquitination, accumulation of damaged mitochondria, severe mitochondrial dysfunction, culminating in dilated cardiomyopathy and heart failure

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References Ellingson, K

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Because IGF-1 LR3 bypasses the pituitary and GH entirely, none of the normal negative feedback systems moderate its effect once injected

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