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Phase 2 trial data (NCT04881760) reported diarrhoea in approximately 2030% of participants at higher doses, with symptoms most pronounced during dose-escalation phases

Based on trial data published to date, the known adverse effect profile of retatrutide includes nausea, vomiting, diarrhoea, decreased appetite, injection site reactions, and increases in resting heart rate

The good news: Retatrutides glucagon activation partially counteracts this metabolic adaptation, allowing continued progress longer than traditional dieting approaches

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Caffeine, too, should be limited or avoided by people with sleep issues, high blood pressure, migraines, or if youre pregnant (limit it to 200mg/day)

The study was funded, in part, by the National Institutes of Health (grants P30 AI036214, UM1 AI068634, UM1 AI068636, UM1 AI106701) and the James B