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At best, about half of all patients become unresponsive to their current therapy and need to be switched up to another, more toxic drug

The specific target, anti-tumor effect, and clinical progress of these inhibitors targeting NADPH metabolism are also summarized in Tables 1 and 2

POI, premature ovarian insufficiency

While the GSNO signal always showed only a small number of counts, it was present in all plasma-treated samples, indicating a stable generation of GSNO by DBD treatment

Lund ME, Banner W, Clarkson TW, et al

In patients with glutathione synthetase deficiency, early diagnosis and initiation of treatment are the most important determinants for outcome and survival (70)