These findings align with a recent study in a comparable HFpEF mouse model (HFD + L-NAME), where cardiomyocytes exhibited increased contractility alongside elevated calcium transients 53
Bouchaoui, H
Furthermore, a diet based on an increased intake of carbohydrates and fats leads to increased production of free radicals, directly affecting mitochondrial metabolism
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Also, there is a need to establish collaborative platforms between interdisciplinary teams, including basic researchers, clinicians, and industry partners, to take bench work to a product or treatment
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