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One-carbon metabolism in cancer

However, under conditions of stress and inhibition of the electron transport chain, the enzyme works in the opposite direction by transferring electrons from NADPH to NAD + , which impairs mitochondrial antioxidant defenses and feeds more reducing equivalents into the impaired electron transport chain leading to increased electron leakage and superoxide formation [133]

The genotoxicity tolerance was improved by modulating the loss of DNA studied through comet assay and related parameters

This study offers useful information on the tolerance and acclimatization of plants to high-temperature stress

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However, on top of the concern for survival and growth of TAM-tolerant cells, there are adverse events (AE) associated with TAM therapy, including hot flashes, increased risk of endometrial cancer, and, in rare instances, liver abnormalities (Viedma-Rodrguez et al., 2014)