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An early clinical trial in 13 patients with type 2 diabetes found that a single intravenous infusion of 1,000 mg of lipoic acid improved insulin-stimulated glucose disposal (i.e., insulin sensitivity) by 50% compared to a placebo infusion (57)

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Conversely, efficient metabolic transitions can benefit health and influence lifespan, as evidenced by reduced disease incidence and prolonged lifespan associated with fasting 2,3,4,5,6