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Goswami, A

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These precise alterations dramatically decrease the peptides affinity for insulin-like growth factor-binding proteins (IGFBP)

This mechanism has been proposed to underlie observations related to tissue matrix integrity noted across multiple research studies

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However, in response to chemical or physical environmental triggers, to certain drugs and hormones, to inflammation, and in association with certain systemic diseases or neoplastic processes, the metabolism of oral melanocytes may increase with consequent increase in biosynthesis of melanin [4, 6]