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Processing Fats The liver is also responsible for metabolizing fats

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In a 10-week clinical trial, a daily dose of 20 mg oral semaglutide achieved a steady-state plasma concentration of 30 nM, and when daily dose of oral semaglutide was increased to 40 mg, the semaglutide plasma concentration reached about 60 nM (102), which was over a thousand times higher than the EC50 of semaglutide for GLP-1R activation (95)

Distinct and Overlapping Functional Roles of GIPR, GLP-1R, and GLP-2R Regulation of Post-prandial Lipid Metabolism Spearman correlations between GLP-1, GLP-2, GIP, and TG responses in plasma during an oral fat tolerance test in obese men reveal a small albeit significant positive correlation ( r -squared values close to zero) between all three hormone area under curves (AUCs) for TG and apoB48 (Matikainen et al., 2016)