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Analytical size exclusion chromatography revealed a native molecular mass of 234,000 Da, which is in agreement with a tetrameric or a pentameric MDH architecture (Figure 2C)

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Here, we use a pooled, dual CRISPR screening strategy that knocks out pairs of transporters in four metabolic states glucose, galactose, OXPHOS inhibition, and absence of pyruvate designed to unmask the inter-dependence of these genes

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They also analyzed dose-response relationships and found no consistent pattern linking higher use to increased riska critical sign that the drug itself is unlikely to be the culprit

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