Potential Side Effects at 4 mg, 9 mg, and 12 mg TRANSCEND-T2D-1 reported nausea in 16.4%, 19.5%, and 26.5% of participants receiving 4 mg, 9 mg, and 12 mg, respectively, compared with 3.7% with placebo [9]
This observation has raised concerns regarding suboptimal drug exposure, altered pharmacokinetics, and heightened inflammatory burden in obese patients, highlighting the potential need for dose optimization or alternative treatment strategies in this population (63, 64)
Scales CD, Smith AC, Hanley JM, Saigal CS, Urologic Dis Amer P (2012) Prevalence of kidney stones in the united States
"The role of glutathione in photosynthetic organisms: emerging functions for glutaredoxins and glutathionylation" (PDF)
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