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Europe sets out to reform its clinical trial rules
Approved for type 2 diabetes management
Neither AOD 9604 nor retatrutide holds a Marketing Authorisation from the MHRA, meaning selling or supplying them with therapeutic claims in the UK is illegal under the Human Medicines Regulations 2012
However, those who maintain intensive lifestyle habits, including regular exercise, show significantly better outcomes
Combination therapy is typically considered for patients with inadequate glycemic control on GLP-1 monotherapy or when cost, adherence, or side effects favor adding an oral DPP-4 rather than increasing GLP-1 dose
& Holland, J
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