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Diabetologia 52 , 15661578 (2009)

Int J Biochem Mol Biol

Competitive or tested athletes BPC-157 has been on the World Anti-Doping Agency Prohibited List under category S0 since 2022 and remains on the 2025 list

The bulky A350 6.39b W and K351 6.40b A mutants almost abolished the maximal response (Emax) of GLP-1R-mediated cAMP accumulation in presence of compound 2, while V332 5.62b A, K346 6.35b A and L349 6.38b A mutants greatly elevated basal cAMP activities but significantly diminished the efficacy of the response upon stimulation by either compound 2 or GLP-1, suggesting these mutations affect the kink of TM6 required for receptor activation

Other therapeutic indications, including colitis, pediatric gastrointestinal disorders and inflammation of the intestinal mucosa, are currently under development