Large meals are hard to tolerate when due to slowed gastric emptying the stomach might still be partially full from your last meal
Diabetes 52:23312337 Pruski M, Krysiak R, Okopien B (2009) Pleiotropic action of short-term metformin and fenofibrate treatment, combined with lifestyle intervention, in type 2 diabetic patients with mixed dyslipidemia
Soreness duration decreases
The patient was started on Tirzepatide one week prior for type 2 diabetes and weight loss
Baci D, Bruno A, Bassani B, Tramacere M, Mortara L, Albini A, Noonan DM
The article describes phentermine as having minimal direct effect on blood sugar while increasing heart rate and blood pressure