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Some genetic variants associated with higher BMI also influence reproductive hormone levels and ovulation patterns

Specific situations requiring medical advice include: consistently elevated blood pressure readings above 140/90 mmHg (or above the individual target set by their healthcare team), symptoms suggesting low blood pressure such as recurrent dizziness or fainting, or any new cardiovascular symptoms including chest pain, palpitations, or unusual shortness of breath

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Semaglutide carries contraindications for individuals with a history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2, or hypersensitivity to semaglutide

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Most of the early experience is therefore retatrutide-monotherapy experience