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These findings suggest that while bitter substances promise to improve glucose homeostasis, their potential adverse effects beyond the gastrointestinal system warrant careful consideration [196]
Supporting this, in a phase 2a trial in people with MASLD, the dual GLP-1/GCG agonist efinopegdutide (10 mg) reduced liver fat by 72.7%, compared to 42.3% with semaglutide (1 mg) despite similar WLindicating potential weight-independent effects of GCG on hepatic steatosis [40]
They wake up feeling less puffy
As insulin levels normalize and drop from previously elevated states, IGF-1 levels may also decline
To address constipation, its essential to prioritize hydration and ensure you are consuming an adequate amount of dietary fiber