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In the case of glucocorticoids, their effect is produced by the direct action of their receptor on the response elements located at the promoter and first exon level (Figure 7), facilitating the access of other transcription factors (especially Pit-1 and CREB) to their specific binding sequences [42]

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Moreover, while sCT was effective in suppressing body weight for 20-days, it lost its potency during the last 10 days