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Recent clinical trials, published in September 2025 in The New England Journal of Medicine , show that high-dose oral semaglutide tablets can deliver weight loss results that begin to approach what we see with injections
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JAMA Netw Open 7:e2436783 Sen S, Potnuru PP, Hernandez N, Kumar A, Maykel JA, Steinhagen RM (2024) Glucagon-like peptide-1 receptor agonist use and residual gastric content before anesthesia