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This intense inflammation is associated with damaging systemic events like oxidative stress, dysregulation of iron homeostasis, hypercoagulability and thrombus formation, acute respiratory distress syndrome, uncontrolled inflammation and organ failure (251257) (Figure 8)

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The coordinates of the -SO 2 H group (wherein the sulfur center adopts the pyramidal geometry and features the lone pair of electrons) were oriented to best fit the map while maximizing polar interactions with the surrounding YPEL5 side chains