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It slows gastric emptying (slow digestion), which is the rate at which food moves through the stomach, making users feel fuller longer

DiNicolantonio JJ, Niazi AK, McCarty MF, Lavie CJ, Liberopoulos E, OKeefe JH, MedReviews LLC (2014) L-carnitine for the treatment of acute myocardial infarction

Lotiglipron The development of lotiglipron for obesity and T2DM was prematurely stopped in early-phase clinical trials due to its association with elevated transaminases and potential liver toxicity

Also notable were disparities in treatment continuation

While these medications don't directly interfere with thyroid function, important safety considerationsincluding thyroid cancer risk factors and potential effects on thyroid hormone absorptionmust be addressed before starting treatment

If you need a broader starting point, the sites What Is Retatrutide explainer gives more background on why researchers are watching this drug class