In one large study, 5,200 women received 1,000 mcg of vitamin B12 daily and other B vitamins and folic acid seven years later
Safety: what we know, what we dont What clinical trial safety reviews suggest The clinical safety review literature reports several reassuring signals: No meaningful increase in IGF-1 in monitored long-term studies (jofem.org) No clear negative effect on carbohydrate metabolism in testing described (contrast with full hGH) (jofem.org) No clear immunogenicity signal (e.g., anti-AOD antibodies) in the subset assessed in those trials (jofem.org) The major limitation: long-term real-world certainty is thin The problem with many peptides is not that everything is dangerousits that the certainty level is often lower than patients assume
The most commonly reported adverse effects are the GI symptoms associated with tirzepatide (nausea, reduced appetite) plus the mild headache occasionally seen with AOD 9604
doi:10.1111/dme.12390
As B12 is essential for the production of red blood cells and proper nervous system function, its deficiency can disrupt these processes and lead to symptoms like gastrointestinal discomfort and poor appetite, which may contribute to unintended weight loss
It helps regulate glycogen, which impacts energy levels