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Butyrate serves as a primary energy source for colonocytes and enhances intestinal barrier integrity by increasing the expression of tight junction proteins like occludin, which is vital for preventing systemic inflammation 34
2.4 TMAO TMAO, a key end-product generated by gut microbiota (Anaerococcus, Clostridium, etc.) through the metabolism of dietary nutrients like choline and lecithin, and subsequently formed via catalysis by hepatic flavin-containing monooxygenases, has emerged as a crucial molecular link connecting gut dysbiosis to the initiation and progression of CRC (Jalandra et al., 2021)
The feeding medium contained 500 g/L glucose and 25 g/L MgSO 4 7H 2 O
Anyone with cancer concerns should discuss Wnt-modulating treatments with an oncologist before use
