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1,2 The results are consistent with actions taken by the European Medicines Agency (EMA) in June 2025, when the agency classified NAION as a very rare side effect of semaglutide and recommended product labeling updates. Epidemiologic data reviewed by the EMA suggested an approximately twofold increased risk in adults with type 2 diabetes, corresponding to roughly one additional case per 10,000 person-years of treatment. The agency advised that patients with sudden vision loss or rapidly worsening eyesight seek immediate medical attention and discontinue treatment if NAION is confirmed. READ MORE: Blinding Disease-Weight Loss Drug Link: EMA Announces Start of Semaglutide Investigation Study strengths Methodologically, the VA study offers several strengths: The analysis leveraged the largest integrated health care system in the United States, with medication exposure confirmed through pharmacy dispensing records rather than prescription data alone

doi: 10.3389/fnut.2023.1134162 Received 30 December 2022 Accepted 22 June 2023 Published 20 July 2023 Volume 10 - 2023 Edited by Xiaoping Yang, Hunan Normal University, China Reviewed by Lorenzo Lorusso, ASST Lecco, Italy

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In type 1 diabetic mice and high glucose-cultured HK-2 cells, it was demonstrated that circ_ASAP2 binding to miR-770-5p reduced inflammation and ferroptosis by regulating the SRY-box transcription factor 2 (SOX2)/SLC7A11 pathway[153]