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The antioxidant Dl-3-n-butylphthalide can hinder the NLRP3 inflammasome and decrease the severity of AD-like symptoms by affecting the Nrf2-TXNIP-TrX pathway (Wang et al., 2019)

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Intravitreal injection of ConA-MelNPs achieves therapeutic efficacy by impeding RPE cell ferroptosis and lethal oxidative stress, consequently restoring retinal homeostasis (163)

Glutathione mechanism Most antioxidants simply neutralize free radicals

The fragment retains the biologically active portion responsible for most therapeutic effects