The principal genetic causes of AD are mutations in different genes, such as APP (Goate et al., 1991), -secretase proteins presenilin-1 and presenilin-2 (PSEN1-2) (Scheuner et al., 1996), which result in the production of aggregation-prone A peptides, called oligomers
Contraindications and Precautions While B12 injections are safe for most, there are some exceptions: Knowing about these side effects and precautions can help avoid risks
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