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Biologically, the mechanistic underpinnings and subtleties of these novel therapeutics are just beginning to be fully understood, with species- and sex-specific differences remaining high priorities in continuing studies

A WIRED investigation last year showed that it was shockingly easy to purchase compounded GLP-1 drugs online, with some telehealth outfits doing little vetting before issuing a prescription

But real-world data tells a more nuanced story

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Some people mistake a properly working dose for "not working" because the effect is subtle at lower levels, but after weeks with no noticeable change, the dose likely needs adjustment

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