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Dosing errors are the most commonly reported issue
It is a deliberate choice by some providers to reduce the incidence of nausea, vomiting, and other gastrointestinal side effects that cause many patients to abandon treatment entirely
& Chung, C
Morrow, J
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Beside lactic acid, the acetic and succinic acids and ethanol produced in substantial amounts by strain ME-3 in microaerobic conditions, the production of NO and H 2 O 2 could be responsible for the antimicrobial effect ( in vitro antagonistic activity, seemingly due to a pH drop and organic acids production, was quite characteristic of particular fermentative groups of lactobacilli (homo-, facultatively heterofermentative and obligately heterofermentative) further identified by ITS-PCR Citation[137]
