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If you have extensive prior experience with tirzepatide at high doses and weigh over 220 pounds, four weeks per level is appropriate, possibly three weeks at the 1 mg level only

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doi: 10.1056/NEJMoa1411892 93 WaddenTAHollanderPKleinSNiswenderKWooVHalePMet al

The caloric deficit is simply too large

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