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These may include the sensation of sand or gravel in the eye or the need to drink liquids frequently to contrast oral dryness ( Systemic manifestations of SS include cryoglobulinemic purpura, non-erosive symmetrical arthritis, interstitial lung disease, Raynaud's phenomenon, pericarditis, autoimmune hepatitis and primary biliary cirrhosis, polyneuropathy, thyroiditis, B cell lymphoma, autoimmune haemolytic anemia, and eventually renal disease, ranging from glomerulonephritis to tubulointerstitial nephritis ( Renal involvement has long been known to be multifaceted and possibly underestimated in SS

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Once transported across the plasma membrane, glucose is metabolically processed via three distinct pathways: glycolysis, the PPP, and the TCA cycle

The transporter encoded by the ATP2B1 gene is identified as PMCA1b (plasma membrane Ca 2+ transporter 1b)