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PBM Innovation in Helping Patients Stay on Medication Delivers Results Pharmacy benefit managers (PBMs) are innovating to help patients access and remain on GLP-1 therapies for weight loss by managing costs and providing wraparound support services that employers can choose to offer

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Moses RG, Round E, Shentu Y et al (2016) A randomized clinical trial evaluating the safety and efficacy of sitagliptin added to the combination of sulfonylurea and metformin in patients with type 2 diabetes mellitus and inadequate glycemic control

Researchers never published the full results, although a short write-up in 2005 reported that the second trial found a positive effect but that it didnt reach statistical significance

Earlier meta-analyses did report a small on-medication motor benefit, roughly one to three points, but that effect is heterogeneous and fragile: in at least one pooled analysis, it lost statistical significance once the lixisenatide trial was removed [8]

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