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Many commercial preparations contain additional ingredients such as: Sorbitol or mannitol sugar alcohols used as sweeteners in some tablets that can cause osmotic diarrhoea when consumed in larger quantities, though the amounts in typical supplements are usually too small to cause symptoms alone [13] [14] Binding agents and fillers including lactose, which may cause symptoms in people with lactose intolerance, though tablet quantities are typically small Other additives various excipients that some individuals may be sensitive to The dose and frequency of supplementation may also influence tolerability
Topical application is generally considered the lowest risk because very little of the ingredient reaches the bloodstream
Beginners should not use it without medical screening, lab review, and ongoing monitoring
10.1186/s12906-023-04150-1 194 QiY.ChengX.JingH.YanT.XiaoF.WuB.et al (2019)
They are not reviewed or approved by the FDA for safety or effectiveness and may be prescribed when FDA-approved alternatives are unavailable or unsuitable
