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Consider adjuncts like metformin, which can enhance insulin resistance and increase endogenous GLP-1 secretion

Inflammation in atherosclerosis: a key role for cytokines

Risks include mild gastrointestinal discomfort, headaches, injection site irritation, and unknown long-term effects

Nutritional strategies form the foundation of craving management: Include adequate protein at each meal (often 20-30g per meal is helpful), as protein promotes satiety and helps stabilise blood glucose levels, reducing the likelihood of sugar cravings Choose complex carbohydrates such as wholegrain bread, brown rice, oats, and pulses, which provide sustained energy release and prevent the blood sugar fluctuations that can trigger sweet cravings Don't restrict calories too severely Wegovy already reduces appetite, so additional extreme restriction may backfire by intensifying cravings Stay well hydrated , as thirst is sometimes misinterpreted as hunger or cravings

Primary mechanism for satiety

Their synthesis occurs through the proteolytic processing of the proglucagon precursor by various prohormone convertases (74)