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Gastroenterology 132 , 21312157 (2007)

Approximately 60 individuals were included in this randomized, triple-blind, placebo-controlled experiment and were given doses ranging from 0.5 g, 1.0 g, and 2.0 g, as well as a placebo group

renal impairment and GI bleeding with overuse of NSAIDS is possible

Although stress is also a factor which may influence someones blood pressure, no doctor treating individuals with hypertension would consider that those needing a higher dose and more different types of blood-pressure-lowering drugs are mentally unstable, making up their disease, or suffering from the placebo effect